Clare, Linda, Bayer, Antony, Burns, Alistair, Corbett, Anne, Jones, Roy, Knapp, Martin, Kopelman, Michael, Kudlicka, Aleksandra, Leroi, Iracema, Oyebode, Jan, Pool, Jackie, Woods, Bob, Whitaker, Rhiannon

Background: Preliminary evidence suggests that goal-oriented cognitive rehabilitation (CR) may be a clinically effective intervention for people with early-stage Alzheimer’s disease, vascular or mixed dementia and their carers. This study aims to establish whether CR is a clinically effective and cost-effective intervention for people with early-stage dementia and their carers.; Methods/design: In this multi-centre, single-blind […]

Clare, Linda, Linden, David E. J., Woods, Robert T, Whitaker, Rhiannon, Evans, Suzannah J., Parkinson, Caroline H., van Paasschen, Jorien, Nelis, Sharon M., Hoare, Zoe, Yuen, Kenneth S. L., Rugg, Michael D.

Objectives: To provide evidence regarding the clinical efficacy of cognitive rehabilitation (CR) in early-stage Alzheimer disease (AD).; Design: Single-blind randomized controlled trial comparing CR with relaxation therapy and no treatment.; Setting: Outpatient, community-based setting.; Participants: Sixty-nine individuals (41 women, 28 men; mean age 77.78 years, standard deviation 6.32, range = 56-89) with a diagnosis of […]

Quinn, L., Debono, K., Dawes, H., Rosser, A. E., Nemeth, A. H., Rickards, H., Tabrizi, S. J., Quarrell, O., Trender-Gerhard, I., Kelson, M. J., Townson, J., Busse, M.

Background: Task-specific training may be a suitable intervention to address mobility limitations in people with Huntington disease (HD).; Objective: The aim of this study was to assess the feasibility and safety of goal-directed, task-specific mobility training for individuals with mid-stage HD.; Design: This study was a randomized, blinded, feasibility trial; participants were randomly assigned to […]