This database contains 21 studies, archived under the term: "gait"
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Is high oral dose L-arginine intake effective in leukoaraiosis? Preliminary data, study protocol and expert’s opinion
Calabro, Rocco Salvatore,
Gervasi, Giuseppe,
Baglieri, Annalisa,
Furnari, Anna,
Marino, Silvia,
Bramanti, Placido
Background: Leukoraraiosis is worldwide considered as a part of the normal aging process, although it is strongly associated with dementia and other disabilities. The pathogenesis of leukoaraiosis still has not been thoroughly acknowledged, even though chronic ischemia with consequent arteriolosclerosis probably due to endothelial dysfunction has been suggested. Treatment focuses on prevention of lesion formation […]
Physical therapy in Huntington’s disease–toward objective assessments?
Bohlen, S.,
Ekwall, C.,
Hellström, K.,
Vesterlin, H.,
Björnefur, M.,
Wiklund, L.,
Reilmann, R.
Background and Purpose: Physical therapy is recommended for the treatment of Huntington’s disease, but reliable studies investigating its efficacy are almost non-existent. This may in part be due to the lack of suitable outcome measures. Therefore, we investigated the applicability of novel quantitative and objective assessments of motor dysfunction in the evaluation of physical therapy […]
Anti-dementia drugs and changes in gait: a pre-post quasi-experimental pilot study
Beauchet, Olivier,
Launay, Cyrille P.,
Allali, Gazan,
Watfa, Gilles,
Gallouj, Karim,
Herrmann, François R.,
Annweiler, Cedric
Background: Anti-dementia drugs may improve gait performance. No comparison between acetylcholinesterase inhibitors (CEIs) and memantine-related changes in gait variability has been reported. The objectives of this study were to 1) quantify and compare the mean values and coefficients of variation (CoV) of stride time in demented patients with Alzheimer’s disease and related disorders (ADRD) before […]
Continuous dopaminergic stimulation by Duodopa in advanced Parkinson’s disease: Efficacy and safety
Annic, A.,
Devos, D.,
Seguy, D.,
Dujardin, K.,
Destée, A.,
Defebvre, L.
Introduction: When advanced Parkinson’s disease (PD) patients experience motor complications (fluctuations and dyskinesias) despite standard oral treatment, two treatment options are available: deep brain stimulation and subcutaneous apomorphine infusion with respects of indications for each strategy. Continuous intraduodenal infusion of levodopa (Duodopa) via a gastrojejunal tube may be proposed at this stage of the disease […]
Effects of a physical training programme on cognitive function and walking efficiency in elderly persons with dementia
Kemoun, Gilles,
Thibaud, Marie,
Roumagne, Nicolas,
Carette, Pierre,
Albinet, Cédric,
Toussaint, Lucette,
Paccalin, Marc,
Dugué, Benoit
Objectives: To study the effects of physical stimulation based on walking exercises, equilibrium and endurance on cognitive function and walking efficiency in patients with dementia.; Methods: Randomized controlled trial including 31 subjects suffering from dementia (age: 81.8 +/- 5.3 years). The intervention group (n = 16) benefited from a 15-week physical activity programme involving three […]
Nursing home resident outcomes from the Res-Care intervention
Resnick, Barbara,
Gruber-Baldini, Ann L.,
Zimmerman, Sheryl,
Galik, Elizabeth,
Pretzer-Aboff, Ingrid,
Russ, Karin,
Hebel, J. Richard
Objectives: To test the effectiveness of a restorative care (Res-Care) intervention on function, muscle strength, contractures, and quality of life of nursing home residents, with secondary aims focused on strengthening self-efficacy and outcome expectations.; Design: A randomized controlled repeated-measure design was used, and generalized estimating equations were used to evaluate status at baseline and 4 […]
V-TIME: a treadmill training program augmented by virtual reality to decrease fall risk in older adults: study design of a randomized controlled trial
Mirelman, Anat,
Rochester, Lynn,
Reelick, Miriam,
Nieuwhof, Freek,
Pelosin, Elisa,
Abbruzzese, Giovanni,
Dockx, Kim,
Nieuwboer, Alice,
Hausdorff, Jeffrey M.
Background: Recent work has demonstrated that fall risk can be attributed to cognitive as well as motor deficits. Indeed, everyday walking in complex environments utilizes executive function, dual tasking, planning and scanning, all while walking forward. Pilot studies suggest that a multi-modal intervention that combines treadmill training to target motor function and a virtual reality […]
Alzheimer’s disease–input of vitamin D with mEmantine assay (AD-IDEA trial): study protocol for a randomized controlled trial
Annweiler, Cedric,
Fantino, Bruno,
Parot-Schinkel, Elsa,
Thiery, Samuel,
Gautier, Jennifer,
Beauchet, Olivier
Background: Current treatments for Alzheimer’s disease and related disorders (ADRD) are symptomatic and can only temporarily slow down ADRD. Future possibilities of care rely on multi-target drugs therapies that address simultaneously several pathophysiological processes leading to neurodegeneration. We hypothesized that the combination of memantine with vitamin D could be neuroprotective in ADRD, thereby limiting neuronal […]