Thiyagesh, Subha N., Farrow, Tom F. D., Parks, Randolph W., Accosta-Mesa, Hector, Hunter, Michael D., Young, Claire, Wilkinson, lain D., Woodruff, Peter W. R.

Background/Aims: Visuospatial impairments are known to occur in Alzheimer’s disease (AD). We hypothesised that functional magnetic resonance imaging (fMRI) response in task-related brain regions would be impaired in patients with AD during the task and that treatment with acetyl cholinesterase inhibitors would enhance activations in brain regions concerned with this visual perceptual processing. Method: Ten […]

Clare, Linda, van Paasschen, Jorien, Evans, Suzannah J., Parkinson, Caroline, Woods, Robert T, Linden, David E. J.

An individual, goal-oriented cognitive rehabilitation intervention was conducted with AB, a 77-year-old woman with MCI. Outcomes were evaluated using a client-centred measure of goal achievement and an experimental associative learning task testing a skill practised in the intervention. Pre- and post-intervention fMRI scans were compared to examine changes in brain activation. Following intervention, AB showed […]

Haller, Sven, Montandon, Marie-Louise, Rodriguez, Cristelle, Moser, Dominik, Toma, Simona, Hofmeister, Jeremy, Sinanaj, Indrit, Lovblad, Karl-Olof, Giannakopoulos, Panteleimon

Previous studies showed that acute caffeine administration enhances task-related brain activation in elderly individuals with preserved cognition. To explore the effects of this widely used agent on cognition and brain activation in early phases of cognitive decline, we performed a double-blinded, placebo-controlled functional magnetic resonance imaging (fMRI) study during an n-back working memory task in […]