Remington, Ruth, Lortie, Jevin J., Hoffmann, Heather, Page, Robert, Morrell, Christopher, Shea, Thomas B.

Thirty-four individuals with mild cognitive impairment were randomized for 6 months to a nutraceutical formulation (NF: folate, alpha-tocopherol, B12, S-adenosyl methioinine, N-acetyl cysteine, acetyl-L-carnitine) or indistinguishable placebo, followed by a 6-month open-label extension in which all individuals received NF. The NF cohort improved in the Dementia Rating Scale (DRS; effect size >0.7) and maintained baseline […]

Chan, Amy, Paskavitz, James, Remington, Ruth, Rasmussen, Shelly, Shea, Thomas B.

We examined the efficacy of a vitamin/nutriceutical formulation (folate, vitamin B6, alpha-tocopherol, S-adenosyl methionine, N-acetyl cysteine, and acetyl- L-carnitine) in a 12-month, open-label trial with 14 community-dwelling individuals with early-stage Alzheimer’s disease. Participants improved in the Dementia Rating Scale and Clock-drawing tests (Clox 1 and 2). Family caregivers reported improvement in multiple domains of the […]

Schiepers, Olga J. G., van Boxtel, Martin P. J., de Groot, Renate H. M., Jolles, Jelle, Kok, Frans J., Verhoef, Petra, Durga, Jane

Long-term supplementation with folic acid may improve cognitive performance in older individuals. The relationship between folate status and cognitive performance might be mediated by changes in methylation capacity, as methylation reactions are important for normal functioning of the brain. Although aberrant DNA methylation has been implicated in neurodevelopmental disorders, the relationship between DNA methylation status […]