Beglinger, Leigh J., Adams, William H., Langbehn, Douglas, Fiedorowicz, Jess G., Jorge, Ricardo, Biglan, Kevin, Caviness, John, Olson, Blair, Robinson, Robert G., Kieburtz, Karl, Paulsen, Jane S.

Background: The objective of this study was to evaluate citalopram for executive functioning in Huntington’s disease (HD).; Methods: The study was randomized, double-blind, and placebo-controlled. Thirty-three adults with HD, cognitive complaints, and no depression (Hamilton Depression [HAM-D] rating scale ≤ 12) were administered citalopram 20 mg or placebo (7 visits, 20 weeks), with practice and […]

Bauer, Lisa, Pozehl, Bunny, Hertzog, Melody, Johnson, Julene, Zimmerman, Lani, Filipi, Mary

Background: Cognitive impairment is a recognized consequence of heart failure; however, there are no neuropsychological batteries with documented psychometric data in the chronic heart failure population.; Aims: To document the psychometric properties of a brief neuropsychological battery in a chronic heart failure sample.; Methods: The Repeatable Battery for the Assessment of Neuropsychological Status, Trail Making […]

Anderson-Hanley, Cay, Arciero, Paul J., Brickman, Adam M., Nimon, Joseph P., Okuma, Naoko, Westen, Sarah C., Merz, Molly E., Pence, Brandt D., Woods, Jeffrey A., Kramer, Arthur F., Zimmerman, Earl A.

Background: Dementia cases may reach 100 million by 2050. Interventions are sought to curb or prevent cognitive decline. Exercise yields cognitive benefits, but few older adults exercise. Virtual reality-enhanced exercise or “exergames” may elicit greater participation.; Purpose: To test the following hypotheses: (1) stationary cycling with virtual reality tours (“cybercycle”) will enhance executive function and […]

Ancelin, Marie-Laure, Carrière, Isabelle, Barberger-Gateau, Pascale, Auriacombe, Sophie, Rouaud, Olivier, Fourlanos, Spiros, Berr, Claudine, Dupuy, Anne-Marie, Ritchie, Karen

The aim of this prospective cohort study was to evaluate the effects of lipid lowering agent (LLA) intake on cognitive function in 6,830 community-dwelling elderly persons. Cognitive performance (global cognitive functioning, visual memory, verbal fluency, psychomotor speed, and executive function), clinical diagnosis of dementia, and fibrate and statin use, were evaluated at baseline, and 2, […]