Kiosses, Dimitris N., Arean, Patricia A., Teri, Linda, Alexopoulos, George S.

Objectives: This preliminary study examines the efficacy of 12-week home-delivered problem adaptation therapy (PATH) versus home-delivered supportive therapy (ST) in reducing depression and disability in 30 depressed, cognitively impaired, disabled older adults.; Design: A 12-week randomized clinical trial. Research assistants were unaware of the participants’ randomization status. Assessments were conducted at baseline, 6 weeks, and […]

Thomas, A. J., Gallagher, P., Robinson, L. J., Porter, R. J., Young, A. H., Ferrier, I. N., O'Brien, J. T.

Background: Neurocognitive impairment is a well-recognized feature of depression that has been reported in younger and older adults. Similar deficits occur with ageing and it is unclear whether the greater deficits in late-life depression are an ageing-related phenomenon or due to a difference in the nature of late-life depression itself. We hypothesized that ageing alone […]

Santangelo, G., Morgante, L., Savica, R., Marconi, R., Grasso, L., Antonini, A., De Gaspari, D., Ottaviani, D., Tiple, D., Simoni, L., Barone, P.

Objective: To assess the psychometric properties of the Italian version of the Snaith-Hamilton Pleasure Scale (SHAPS) and to study the relationship between anhedonia, depression and cognitive impairment in patients with Parkinson’s disease (PD).; Methods: The SHAPS (14 items) was translated into Italian and pre-tested in a pilot study. Two items evaluating physical anhedonia related to […]

Holl, Anna K., Wilkinson, Leonora, Painold, Annamaria, Holl, Etienne M., Bonelli, Raphael M.

Patients with Huntington’s disease (HD) often suffer from psychiatric symptoms including affective disorder, psychosis, irritability, and apathy, which may be present in all stages of the disease. However–despite the obvious likelihood that these symptoms may be reduced by antidepressive treatments–to date, the effectiveness of such treatments in HD has only ever been examined in case […]

Brommelhoff, Jessica A., Gatz, Margaret, Johansson, Boo, McArdle, John J., Fratiglioni, Laura, Pedersen, Nancy L.

This study tested whether history of depression is associated with an increased likelihood of dementia, and whether a first depressive episode earlier in life is associated with increased dementia risk, or whether only depressive episodes close in time to dementia onset are related to dementia. Depression information came from national hospital discharge registries, medical history, […]