Sakakibara, Ryuji, Ogata, Takeshi, Uchiyama, Tomoyuki, Kishi, Masahiko, Ogawa, Emina, Isaka, Shigeo, Yuasa, Joji, Yamamoto, Tatsuya, Ito, Takashi, Yamanishi, Tomonori, Awa, Yusuke, Yamaguchi, Chiharu, Takahashi, Osamu

Although urinary incontinence inevitably occurs in advanced stages of dementia of any etiology, urinary urgency or frequency, also called an overactive bladder (OAB), occurs more commonly in dementia with Lewy bodies (DLB) and vascular dementia than it does in Alzheimer’s disease (AD). Acetylcholinesterase (AChE) inhibitors for dementia and anticholinergics for OAB have been widely used, […]

Nelson, Peter T., Kryscio, Richard J., Abner, Erin L., Schmitt, Frederick A., Jicha, Gregory A., Mendiondo, Marta S., Cooper, Greg, Smith, Charles B., Markesbery, William R.

Dementia can be caused by different diseases including Alzheimer’s disease (AD), dementia with Lewy bodies (DLB), or both (AD + DLB). University of Kentucky AD Center pathologically-diagnosed AD and AD + DLB cases were evaluated who had three or more longitudinal antemortem mental status examinations (n = 156). Patients with important concomitant pathology (n = […]

RICE, Timothy, DOBRY, Yuriy, WANG, Eugene, NOVAKOVIC, Vladan, SHER, Leo

A recent large-scale randomized controlled clinical trial, the Clinical Antipsychotic Trials of Intervention Effectiveness-Alzheimer’s Disease study, found a significant worsening of cognitive functioning in a sample of patients with Alzheimer’s disease. To date there have been no equally powered studies examining the cognitive effects of atypical antipsychotics in patients with dementia with Lewy bodies, the […]

O'Brien, J. T., Firbank, M. J., Davison, C., Barnett, N., Bamford, C., Donaldson, C., Olsen, K., Herholz, K., Williams, D., Lloyd, J.

Unlabelled: Brain imaging with glucose ((18)F-FDG) PET or blood flow (hexamethylpropyleneamine oxime) SPECT is widely used for the differential diagnosis of dementia, though direct comparisons to clearly establish superiority of one method have not been undertaken.; Methods: Subjects with Alzheimer disease (AD; n = 38) and dementia with Lewy bodies (DLB; n = 30) and […]