Rinne, Juha O., Brooks, David J., Rossor, Martin N., Fox, Nick C., Bullock, Roger, Klunk, William E., Mathis, Chester A., Blennow, Kaj, Barakos, Jerome, Okello, Aren A., Rodriguez Martinez de Liano, Sofia, Liu, Enchi, Koller, Martin, Gregg, Keith M., Schenk, Dale, Black, Ronald, Grundman, Michael

Background: Carbon-11-labelled Pittsburgh compound B ((11)C-PiB) PET is a marker of cortical fibrillar amyloid-beta load in vivo. We used (11)C-PiB PET to investigate whether bapineuzumab, a humanised anti-amyloid-beta monoclonal antibody, would reduce cortical fibrillar amyloid-beta load in patients with Alzheimer’s disease.; Methods: Patients with mild-to-moderate Alzheimer’s disease were randomly assigned to receive intravenous bapineuzumab or […]

Rasgon, Natalie L., Geist, Cheri L., Kenna, Heather A., Wroolie, Tonita E., Williams, Katherine E., Silverman, Daniel H. S.

The objective of this study was to examine the effects of estrogen-based hormone therapy (HT) on regional cerebral metabolism in postmenopausal women (mean age = 58, SD = 5) at risk for development of dementia. The prospective clinical trial design included pre- and post-intervention neuroimaging of women randomized to continue (HT+) or discontinue (HT2) therapy […]

Martorana, Alessandro, Di Lorenzo, Francesco, Esposito, Zaira, Lo Giudice, Temistocle, Bernardi, Giorgio, Caltagirone, Carlo, Koch, Giacomo

Dopamine is a neurotransmitter involved in several brain functions ranging from emotions control, movement organization to memory formation. It is also involved in the regulation of mechanisms of synaptic plasticity. However, its role in Alzheimer’s disease (AD) pathogenesis is still puzzling. Several recent line of research instead indicates a clear role for dopamine in both […]