O'Caoimh, Rónán, Healy, Liam, Gao, Yang, Svendrovski, Anton, Kerins, David M., Eustace, Joseph, Kehoe, Patrick Gavin, Guyatt, Gordon, Molloy, D. William

Background: Centrally acting angiotensin converting enzyme inhibitors (CACE-Is) are associated with reduced rates of cognitive decline in patients with dementia. CACE-Is may also improve exercise tolerance in functionally impaired older adults with normal cognition, suggesting that CACE-Is may positively influence activities of daily living (ADL) in dementia.; Objective: To compare rates of decline in patients […]

Mowszowski, Loren, Hermens, Daniel F., Diamond, Keri, Norrie, Louisa, Cockayne, Nicole, Ward, Philip B., Hickie, Ian B., Lewis, Simon J. G., Batchelor, Jennifer, Naismith, Sharon L.

Background: With predicted increases in dementia incidence, interventions targeting neuroplasticity and neuroprotection are required. Cognitive Training (CT) is an intervention which has been shown to improve aspects of cognition, but the pathophysiological mechanisms contributing to its efficacy are unknown. Objective:We aimed to explore the neurobiological correlates of CT using Mismatch Negativity (MMN), a neurophysiological marker […]

Miller, Karen J., Dye, Richelin V., Kim, Jeanne, Jennings, Julia L., O'Toole, Elizabeth, Wong, Julie, Siddarth, Prabha

Objectives: Research indicates an association between stimulating mental activities and better memory performance as people age, but studies on computerized mental stimulation programs are limited. We explored whether computerized brain training exercises improved cognitive performance in older adults.; Methods: In local retirement communities, a convenience sample was randomized into an intervention group (N = 36), […]

Kazui, Hiroaki, Mori, Etsuro, Hashimoto, Masaaki, Ishikawa, Masatsune, Hirono, Nobutsugu, Takeda, Masatoshi

Background/aims: Patients with idiopathic normal pressure hydrocephalus (iNPH) are often given shunt operations to reduce the triad symptoms (cognitive impairment, gait disturbance and urinary disturbance). We examined whether they also reduce caregiver burden.; Methods: The personal strain (PS) and role strain (RS) factors, which are related to the stress and constraints, respectively, on the caregivers […]

Glueckauf, Robert L., Davis, W. Shuford, Willis, Floyd, Sharma, Dinesh, Gustafson, David J., Hayes, Jocelyn, Stutzman, Mary, Proctor, James, Kazmer, Michelle M., Murray, Leticia, Shipman, Judith, McIntyre, Vera, Wesley, Lonnie, Schettini, Gabriel, Xu, Jian, Parfitt, Francine, Graff-Radford, Neill, Baxter, Cynthia, Burnett, Kathleen, Noël, La Tonya, Haire, Kambria, Springer, Jane

Objectives: Discuss initial findings of a randomized clinical trial comparing the effects of telephone-based and face-to-face (f-to-f) cognitive-behavioral therapy (CBT) on changes in caregiver (CG) burden, assistance support, depression, and health status for African American (AA) CGs with depression.; Design: Pilot study using a prepost, two-group design with 14 enrolled and randomized participants.; Measures: Subjective […]

Finn, Maurice, McDonald, Skye

The results of a pilot randomised controlled trial of computerised cognitive training in older adults with mild cognitive impairment (MCI) are reported. Participants (N = 25) were randomised into either the treatment or waitlist training groups. Sixteen participants completed the 30-session computerised cognitive training program using exercises that target a range of cognitive functions including […]

Fernández-Calvo, Bernardino, Contador, Israel, Serna, Adriana, de Lucena, Virginia Menezes, Ramos, Francisco

The study aimed to verify whether the format of an individual or group intervention, applied in a multimodal cognitive stimulation program (MCSP), had an impact on progression and behavioral disturbances associated with Alzheimer’s disease patients (AD). Forty-five participants diagnosed with probable AD were randomly divided into 3 groups. The performance of both experimental groups, receiving […]