Akhondzadeh, Shahin, Shafiee Sabet, Mehdi, Harirchian, Mohammad Hossein, Togha, Mansoreh, Cheraghmakani, Hamed, Razeghi, Soodeh, Hejazi, Seyyed Shamssedin, Yousefi, Mohammad Hossein, Alimardani, Roozbeh, Jamshidi, Amirhossein, Rezazadeh, Shams-Ali, Yousefi, Aboulghasem, Zare, Farhad, Moradi, Atbin, Vossoughi, Ardalan

Rationale: There is increasing evidence to suggest the possible efficacy of Crocus sativus (saffron) in the management of Alzheimer’s disease (AD).; Objective: The purpose of the present investigation was to assess the efficacy of C. sativus in the treatment of patients with mild-to-moderate AD.; Methods: Fifty-four Persian-speaking adults 55 years of age or older who […]

Akhondzadeh, S., Sabet, M. Shafiee, Harirchian, M. H., Togha, M., Cheraghmakani, H., Razeghi, S., Hejazi, S. Sh, Yousefi, M. H., Alimardani, R., Jamshidi, A., Zare, F., Moradi, A.

What Is Known: Herbal medicines have been used in the treatment of behavioural and psychological symptoms of dementia but with variable response. Crocus sativus (saffron) may inhibit the aggregation and deposition of amyloid β in the human brain and may therefore be useful in Alzheimer’s disease (AD).; Objective: The goal of this study was to […]

Krikorian, Robert, Nash, Tiffany A., Shidler, Marcelle D., Shukitt-Hale, Barbara, Joseph, James A.

Concord grape juice contains polyphenol compounds, which have antioxidant and anti-inflammatory properties and influence neuronal signalling. Concord grape juice supplementation has been shown to reduce inflammation, blood pressure and vascular pathology in individuals with CVD, and consumption of such flavonoid-containing foods is associated with a reduced risk for dementia. In addition, preliminary animal data have […]

Mori, Koichiro, Inatomi, Satoshi, Ouchi, Kenzi, Azumi, Yoshihito, Tuchida, Takashi

A double-blind, parallel-group, placebo-controlled trial was performed on 50- to 80-year-old Japanese men and women diagnosed with mild cognitive impairment in order to examine the efficacy of oral administration of Yamabushitake (Hericium erinaceus), an edible mushroom, for improving cognitive impairment, using a cognitive function scale based on the Revised Hasegawa Dementia Scale (HDS-R). After 2 […]

Urso, Elena, Le Pera, Maria, Bossio, Sabrina, Sprovieri, Teresa, Qualtieri, Antonio

Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) has been applied to the analysis of a wide range of biomolecules. To date, there are two specific areas of application where MALDI-TOF-MS is viewed as impractical: analysis of low-mass analytes and relative quantitative applications. However, these limitations can be overcome and quantification can be routine. Increased levels […]

O'Connor, Daniel W., Eppingstall, Barbara, Taffe, John, van der Ploeg, Eva S

Background: Lavender essential oil shows evidence of sedative properties in neurophysiological and animal studies but clinical trials of its effectiveness as a treatment of agitation in people with dementia have shown mixed results. Study methods have varied widely, however, making comparisons hazardous. To help remedy previous methodological shortcomings, we delivered high grade lavender oil in […]

Lewis, John E., McDaniel, H. Reginald, Agronin, Marc E., Loewenstein, David A., Riveros, Jorge, Mestre, Rafael, Martinez, Mairelys, Colina, Niurka, Abreu, Dahlia, Konefal, Janet, Woolger, Judi M., Ali, Karriem H.

Alzheimer’s disease (AD) is a leading killer of Americans, imparts a significant toll on the quality of life of the patient and primary caregiver, and results in inordinate costs in an already overburdened medical system. Prior studies on cholinesterase inhibitors among AD patients have shown minimal amelioration of disease symptoms and/or restoration of lost cognitive […]

Darreh-Shori, Taher, Hosseini, Sharokh Makvand, Nordberg, Agneta

Despite three decades of intensive research in the field of Alzheimer’s disease (AD) and numerous clinical trials of new therapeutic agents, cholinesterase inhibitors (ChEIs) are still the mainstay of therapeutics for AD and dementia with Lewy bodies. Pharmacodynamic analyses of ChEIs provide paradoxical observations. Treatment with the rapidly reversible, noncarbamylating ChEIs (donepezil, galantamine, and tacrine) […]