Volandes, Angelo E., Paasche-Orlow, Michael K., Barry, Michael J., Gillick, Muriel R., Minaker, Kenneth L., Chang, Yuchiao, Cook, E. Francis, Abbo, Elmer D., El-Jawahri, Areej, Mitchell, Susan L.

Objective: To evaluate the effect of a video decision support tool on the preferences for future medical care in older people if they develop advanced dementia, and the stability of those preferences after six weeks.; Design: Randomised controlled trial conducted between 1 September 2007 and 30 May 2008. Setting Four primary care clinics (two geriatric […]

Mühlau, M., Wohlschläger, A. M., Gaser, C., Valet, M., Weindl, A., Nunnemann, S., Peinemann, A., Etgen, T., Ilg, R.

Background and Purpose: Voxel-based morphometry (VBM) has proved a powerful method to detect subtle changes of gray matter (GM) at the group level but the role of VBM for the detection of GM changes in single subjects, especially in those with suspected neurodegenerative disorder, remains uncertain. Here, we performed single subject analyses in 22 patients […]

Tan, R. S.

Objective: To describe the effect of testosterone replacement therapy (TRT) on the brain activity of two demented, hypogonadal male patients with early and late-stage Alzheimer’s disease (AD), respectively.; Methods: We describe the clinical and positron emission tomography (PET) findings for two individuals, one with early stage and the other with late-stage Alzheimer’s disease, before and […]

Rasgon, Natalie L., Kenna, Heather A., Wroolie, Tonita E., Williams, Katherine E., DeMuth, Bevin N., Silverman, Daniel H. S.

Insulin resistance (IR) is a putative risk factor for cognitive decline and dementia, and has been shown to impede neuronal glucose metabolism in animal models. This post hoc study focused on metabolic changes in the medial prefrontal region, a brain region exhibiting decline years before documented cognitive changes, relative to high or low IR status […]

Ott, Carol H., Kelber, Sheryl T., Blaylock, Michele

A multicomponent intervention targeting grief symptoms in spouse caregivers of individuals with dementia was pilot tested in this feasibility study. Twenty spouse caregivers completed the study within the 5-month protocol. The five-component intervention, deduced from Meuser, Marwit, and Sanders’ Dementia Caregiver Grief Model and tailored to participants’ grief, mental health, and learning needs, included supportive […]

Martorana, Alessandro, Di Lorenzo, Francesco, Esposito, Zaira, Lo Giudice, Temistocle, Bernardi, Giorgio, Caltagirone, Carlo, Koch, Giacomo

Dopamine is a neurotransmitter involved in several brain functions ranging from emotions control, movement organization to memory formation. It is also involved in the regulation of mechanisms of synaptic plasticity. However, its role in Alzheimer’s disease (AD) pathogenesis is still puzzling. Several recent line of research instead indicates a clear role for dopamine in both […]