Su, Tsung-Wei, Wu, Li-Ling, Lin, Ching-Po

Objective: This study investigated the prevalence of depression and dementia in long-term institutionalized older leprosy patients in Taiwan. We then examined the effectiveness of reminiscence group therapy on depressive symptoms and cognitive function in this population.; Methods: We recruited 129 long-term institutionalized older leprosy patients in Taiwan and used the Geriatric Depression Scale-Short Form (GDS-SF), […]

Russo, María Julieta, Iturry, Mónica, Sraka, María Alejandra, Bartoloni, Leonardo, Carnero Pardo, Cristóbal, Allegri, Ricardo Francisco

Phototest is a simple, easy and very brief test with theoretical advantages over available dementia screening tests in Spain. The objective of this study was to estimate the diagnostic accuracy of the Phototest for cognitive impairment and dementia and to compare it with that of the MMSE and the Clock Drawing Test (CDT) in an […]

Wang, Lucy Y., Shofer, Jane B., Rohde, Kirsten, Hart, Kim L., Hoff, David J., McFall, Yun H., Raskind, Murray A., Peskind, Elaine R.

Objectives: Agitation/aggression in Alzheimer disease (AD) is a major cause of patient distress, caregiver burden, and institutionalization. Enhanced behavioral responsiveness to central nervous system norepinephrine (NE) release may contribute to the pathophysiology of agitation/aggression in AD. Prazosin, a nonsedating generic medication used for hypertension and benign prostatic hypertrophy, antagonizes NE effects at brain postsynaptic alpha-1 […]

van Dyck, Christopher H., Lyness, Jeffrey M., Rohrbaugh, Robert M., Siegal, Alan P.

Background: The aim of this study is to determine whether B12 replacement would ameliorate cognitive and psychiatric symptoms in elderly subjects with dementia and low serum B12 levels.; Methods: A test group (n = 28) of nursing home residents with low serum B12 levels (300 pg/mL) were evaluated by blinded raters while the test group […]

Kavanagh, Shane, Van Baelen, Bart, Schäuble, Barbara

In Alzheimer’s disease (AD), it is important to consider long-term effects, not only in patients receiving treatment, but also in subjects in whom therapy has been discontinued. The present analysis evaluates the long-term effects of galantamine on cognitive function in AD in terms of Mini-Mental State Examination (MMSE) scores for up to 7 years, using […]

Jha, Arun, Jan, Farida, Gale, Tim, Newman, Charmaine

Objective: To investigate whether recovery-orientated psychiatric assessment and therapeutic intervention enhances the wellbeing of people with dementia and their family carers.; Methods: In a preliminary randomised controlled trial, 48 people with early dementia were recruited. Of 34 who completed the trial, 17 were in the recovery and 17 in the treatment as usual group. Recovery […]