This database contains 6 studies, archived under the term: "brain ischemia"
Spine Surgery under general anesthesia may not increase the risk of Alzheimer’s disease
Background: Volatile anesthetics cause Alzheimer’s disease (AD)-like neuropathology in animals. We determined whether spine surgery under general anesthesia and anesthetic choice contributed to AD development.; Methods: We searched the Clinical Data Repository of the University of Virginia for patients receiving spine surgery from January 1, 1992 to March 1, 2004. Patients with newly-diagnosed AD after […]
Postmenopausal hormone therapy and subclinical cerebrovascular disease: the WHIMS-MRI Study
Coker, L. H.,
Hogan, P. E.,
Bryan, N. R.,
Kuller, L. H.,
Margolis, K. L.,
Bettermann, K.,
Wallace, R. B.,
Lao, Z.,
Freeman, R.,
Stefanick, M. L.,
Shumaker, S. A.
Objective: The Women’s Health Initiative Memory Study (WHIMS) hormone therapy (HT) trials reported that conjugated equine estrogen (CEE) with or without medroxyprogesterone acetate (MPA) increases risk for all-cause dementia and global cognitive decline. WHIMS MRI measured subclinical cerebrovascular disease as a possible mechanism to explain cognitive decline reported in WHIMS.; Methods: We contacted 2,345 women […]
Promotion of the mind through exercise (PROMoTE): a proof-of-concept randomized controlled trial of aerobic exercise training in older adults with vascular cognitive impairment
Liu-Ambrose, Teresa,
Eng, Janice J.,
Boyd, Lara A.,
Jacova, Claudia,
Davis, Jennifer C.,
Bryan, Stirling,
Lee, Philip,
Brasher, Penny,
Hsiung, Ging-Yuek R.
Background: Sub-cortical vascular ischaemia is the second most common etiology contributing to cognitive impairment in older adults, and is frequently under-diagnosed and under-treated. Although evidence is mounting that exercise has benefits for cognitive function among seniors, very few randomized controlled trials of exercise have been conducted in populations at high-risk for progression to dementia. Aerobic-based […]
Impaired glucose metabolism slows executive function independent of cerebral ischemic lesions in Japanese elderly: the Takahata study
Takahashi, Yoshimi,
Iseki, Chifumi,
Wada, Manabu,
Momma, Tadasuke,
Ueki, Masao,
Kawanami, Toru,
Daimon, Makoto,
Suzuki, Kyoko,
Tamiya, Gen,
Kato, Takeo
Objective: Age is known to influence the risk of both cerebral ischemic lesions and impaired cognitive function. Diabetes mellitus (DM) can also be associated with cognitive impairment. However, there has been no study of neuropsychological performance in association with glucose metabolism status and cerebral ischemic lesions in same-aged, community-dwelling elderly persons. The present study was […]