Uenaka, Kazunori, Nakano, Masako, Willis, Brian A., Friedrich, Stuart, Ferguson-Sells, Lisa, Dean, Robert A., Ieiri, Ichiro, Siemers, Eric R.

Objectives: Solanezumab is a humanized anti-amyloid β monoclonal antibody being developed as a passive immunization treatment to slow the progression of Alzheimer disease (AD). Pharmacokinetics (PK), pharmacodynamics, safety, and tolerability after a single dose of solanezumab were compared between Japanese and white patients with AD.; Methods: Japanese and white patients with mild to moderate AD […]

Cumming, Toby B., Blomstrand, Christian, Bernhardt, Julie, Linden, Thomas

Background: Cognitive impairment is an important but underrecognised consequence of stroke. We investigated whether a subset of items from the NIH Stroke Scale (NIHSS) could yield valid information on cognitive status in a group of stroke patients.; Methods: 149 stroke patients from the Göteborg 70+ Stroke Study were investigated after 18 months. We extracted 4 […]

Wessels, Alette M., Pollock, Bruce G., Anyama, Norbert G., Schneider, Lon S., Lieberman, Jeffrey A., Marder, Stephen R., Bies, Robert R.

Risperidone has been used to treat behavioral symptoms, such as delusions and agitation, in people with Alzheimer’s disease. The relationship between magnitude and variability of risperidone and 9-hydroxy risperidone exposure and the relationship with time to discontinuation of the medication were explored. Sixty-five subjects from the Clinical Antipsychotic Trial of Intervention Effectiveness-Alzheimer’s Disease Trial that […]

Haense, C., Herholz, K., Jagust, W. J., Heiss, W. D.

Aim: We investigated the performance of FDG PET using an automated procedure for discrimination between Alzheimer’s disease (AD) and controls, and studied the influence of demographic and technical factors.; Methods: FDG PET data were obtained from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) [102 controls (76.0 +/- 4.9 years) and 89 AD patients (75.7 +/- 7.6 […]

Wolinsky, Fredric D., Vander Weg, Mark W., Howren, M. Bryant, Jones, Michael P., Dotson, Megan M.

Background: Age-related cognitive decline is common and may lead to substantial difficulties and disabilities in everyday life. We hypothesized that 10 hours of visual speed of processing training would prevent age-related declines and potentially improve cognitive processing speed.; Methods: Within two age bands (50-64 and ≥ 65) 681 patients were randomized to (a) three computerized […]

Travers, Catherine, Byrne, G. J., Pachana, N. A., Klein, K., Gray, L.

Objective: To compare the diagnostic accuracy of the interRAI Acute Care (AC) Cognitive Performance Scale (CPS2) and the Mini-Mental State Examination (MMSE), against independent clinical diagnosis for detecting dementia in older hospitalized patients.; Design, Setting, and Participants: The study was part of a prospective observational cohort study of patients aged ≥70 years admitted to four […]

Papp, Edina, Pákáski, Magdolna, Drótos, Gergely, Kálmán, János

Introduction: Early recognition of mild cognitive impairment (MCI) has increasing clinical relevance in the treatment process of dementia, since it is considered as prodromal period. A great variety of instruments have been developed for measuring cognitive performance of the demented patients. The cognitive subscale of the Alzheimer’s Disease Assessment Scale (ADAS-Cog) is one of the […]

Dodel, Richard, Rominger, Axel, Bartenstein, Peter, Barkhof, Frederik, Blennow, Kaj, Förster, Stefan, Winter, Yaroslav, Bach, Jan-Philipp, Popp, Julius, Alferink, Judith, Wiltfang, Jens, Buerger, Katharina, Otto, Markus, Antuono, Piero, Jacoby, Michael, Richter, Ralph, Stevens, James, Melamed, Isaac, Goldstein, Jerome, Haag, Stefan, Wietek, Stefan, Farlow, Martin, Jessen, Frank

Background: Three small trials suggest that intravenous immunoglobulin can affect biomarkers and symptoms of mild-to-moderate Alzheimer’s disease. We tested the safety, effective dose, and infusion interval of intravenous immunoglobulin in such patients.; Methods: We did a multicentre, placebo-controlled phase 2 trial at seven sites in the USA and five in Germany. Participants with probable Alzheimer’s […]

Allgaier, Antje-Kathrin, Kramer, Dietmar, Mergl, Roland, Fejtkova, Sabina, Hegerl, Ulrich

Objective: To assess and compare the validity of the German 15-item version and shortened versions of the Geriatric Depression Scale (GDS) for early detection of depression in nursing home residents with mild to moderate cognitive impairment (MMSE ≥ 15).; Methods: Data from 92 patients were analysed. The Structural Clinical Interview for DSM-IV (SCID) was used as […]