Testad, Ingelin, Ballard, Clive, Brønnick, Kolbjørn, Aarsland, Dag

Introduction: Agitation is common in dementia and is associated with use of restraints and use of psychotropic drugs. The aim of this study was to determine whether an education and supervision intervention could reduce agitation and the use of restraints and antipsychotic drugs in nursing homes.; Method: Four Norwegian nursing homes were randomly allocated to […]

Eggermont, Laura H.P., de Vries, Kerst, Scherder, Erik J.A.

Background: Most studies examining psychotropic medication use on cognition in older persons with dementia include measures of global cognitive function. The present study examined the relationship between different types of psychotropic medication and specific cognitive functions in older people with dementia.; Methods: Two hundred and six institutionalized older adults with dementia (180 women, mean age […]

RICE, Timothy, DOBRY, Yuriy, WANG, Eugene, NOVAKOVIC, Vladan, SHER, Leo

A recent large-scale randomized controlled clinical trial, the Clinical Antipsychotic Trials of Intervention Effectiveness-Alzheimer’s Disease study, found a significant worsening of cognitive functioning in a sample of patients with Alzheimer’s disease. To date there have been no equally powered studies examining the cognitive effects of atypical antipsychotics in patients with dementia with Lewy bodies, the […]

Laredo, Leonor, Vargas, Emilio, Blasco, Antonio Javier, Aguilar, Maria Dolores, Moreno, Alfonso, Portolés, Antonio

Objectives: To explore the association between use of antipsychotics and risk of cerebrovascular accident (CVA) in individuals with dementia aged 65 and older.; Design: Population-based case-control study.; Setting: UK-based electronic primary care records in the General Practice Research Database (GPRD).; Participants: Individuals with dementia aged 65 and older registered in the database between January 1, […]