This database contains 73 studies, archived under the term: "aging"
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Aerobic exercise increases hippocampal volume in older women with probable mild cognitive impairment: a 6-month randomised controlled trial
ten Brinke, Lisanne F.,
Bolandzadeh, Niousha,
Nagamatsu, Lindsay S.,
Hsu, Chun Liang,
Davis, Jennifer C.,
Miran-Khan, Karim,
Liu-Ambrose, Teresa
Background: Mild cognitive impairment (MCI) is a well-recognised risk factor for dementia and represents a vital opportunity for intervening. Exercise is a promising strategy for combating cognitive decline by improving brain structure and function. Specifically, aerobic training (AT) improved spatial memory and hippocampal volume in healthy community-dwelling older adults. In older women with probable MCI, […]
A Nutritional Formulation for Cognitive Performance in Mild Cognitive Impairment: A Placebo-Controlled Trial with an Open-Label Extension
Remington, Ruth,
Lortie, Jevin J.,
Hoffmann, Heather,
Page, Robert,
Morrell, Christopher,
Shea, Thomas B.
Thirty-four individuals with mild cognitive impairment were randomized for 6 months to a nutraceutical formulation (NF: folate, alpha-tocopherol, B12, S-adenosyl methioinine, N-acetyl cysteine, acetyl-L-carnitine) or indistinguishable placebo, followed by a 6-month open-label extension in which all individuals received NF. The NF cohort improved in the Dementia Rating Scale (DRS; effect size >0.7) and maintained baseline […]
Decreased self-reported cognitive failures after memory training
In recent years, attention has been focused on investigating the effectiveness of composite memory intervention programs with different age and diagnostics groups. The goal of this study was to measure changes in cognitive lapses by Cognitive Failure Questionnaire (CFQ) in a large trained, dementia free group (Mini-Mental State Examination [MMSE] > 26). The CFQ was […]
Vitamins B₁₂, B₆, and folic acid for cognition in older men
Ford, A. H.,
Flicker, L.,
Alfonso, H.,
Thomas, J.,
Clarnette, R.,
Martins, R.,
Almeida, O. P.
[Correction Notice: An erratum for this article was reported in Vol 77(8) of Neurology (see record [rid]2011-21984-022[/rid]). In the original article, the daily dose of vitamin B12 used in the trial was reported as 400 μg, but it should have been 500 μg.] Objective: To investigate whether supplementing older men with vitamins B12, B6, and […]
Addressing population aging and Alzheimer’s disease through the Australian Imaging Biomarkers and Lifestyle Study: Collaboration with the Alzheimer’s Disease Neuroimaging Initiative
Ellis, Kathryn A.,
Rowe, Christopher C.,
Villemagne, Victor L.,
Martins, Ralph N.,
Masters, Colin L.,
Salvado, Olivier,
Szoeke, Cassandra,
Ames, David
The Australian Imaging Biomarkers and Lifestyle (AIBL) study is a longitudinal study of 1112 volunteers from healthy, mild cognitive impairment, and Alzheimer’s disease (AD) populations who can be assessed and followed up for prospective research into aging and AD. AIBL aims to improve understanding of the pathogenesis, early clinical manifestation, and diagnosis of AD, and […]
Effect of physical activity on cognitive function in older adults at risk for Alzheimer disease: A randomized trial
Lautenschlager, Nicola T.,
Cox, Kay L.,
Flicker, Leon,
Foster, Jonathan K.,
van Bockxmeer, Frank M.,
Xiao, Jianguo,
Greenop, Kathryn R.,
Almeida, Osvaldo P.
Context: Many observational studies have shown that physical activity reduces the risk of cognitive decline; however, evidence from randomized trials is lacking. Objective: To determine whether physical activity reduces the rate of cognitive decline among older adults at risk. Design and Setting: Randomized controlled trial of a 24-week physical activity intervention conducted between 2004 and […]
Translating the REACH caregiver intervention for use by area agency on aging personnel: The REACH OUT Program
Burgio, Louis D.,
Collins, Irene B.,
Schmid, Bettina,
Wharton, Tracy,
McCallum, Debra,
DeCoster, Jamie
Purpose: The aim of this study was to translate the evidence-based Resources for Enhancing Alzheimer’s Caregiver Health (REACH) II intervention for use in 4 Area Agencies on Aging (AAAs). A secondary aim was to examine possible moderators of treatment outcome. Design and Methods: We used a quasi-experimental pre-post treatment design with no control group. A […]