Shinto, Lynne, Quinn, Joseph, Montine, Thomas, Dodge, Hiroko H., Woodward, William, Baldauf-Wagner, Sara, Waichunas, Dana, Bumgarner, Lauren, Bourdette, Dennis, Silbert, Lisa, Kaye, Jeffrey

Oxidative stress, inflammation, and increased cholesterol levels are all mechanisms that have been associated with Alzheimer’s disease (AD) pathology. Several epidemiologic studies have reported a decreased risk of AD with fish consumption. This pilot study was designed to evaluate the effects of supplementation with omega-3 fatty acids alone (ω-3) or omega-3 plus alpha lipoic acid […]

Prieto-Alhambra, D., Judge, A., Arden, N. K., Cooper, C., Lyles, K. W., Javaid, M. K.

Unlabelled: Patients with cognitive impairment (CI) often do not receive secondary fracture prevention. Use of zoledronic acid led to a similar reduction in re-fracture risk but the survival benefit was limited to those without CI.; Introduction: We tested whether the effects of id (Zol) on re-frazoledronic accture and mortality differed in patients presenting with a […]

O'Callaghan, Nathan, Parletta, Natalie, Milte, Catherine M., Benassi-Evans, Bianca, Fenech, Michael, Howe, Peter R.C.

Objectives: Excessive shortening of the telomeric ends of chromosomes is a marker of accelerated aging. Oxidative stress and nutritional deficiency may influence this process. The aim of this study was to investigate the effect of ω-3 polyunsaturated fatty acid (ω-3 PUFA) supplementation on telomeric shortening in elderly individuals with mild cognitive impairment (MCI).; Methods: Thirty-three […]

Faxén Irving, Gerd, Freund-Levi, Yvonne, Eriksdotter-Jönhagen, Maria, Basun, Hans, Brismar, Kerstin, Hjorth, Erik, Palmblad, Jan, Vessby, Bengt, Vedin, Inger, Wahlund, Lars-Olof, Cederholm, Tommy

Objectives: To study the effects of omega (Omega)-3 fatty acid (FA) supplements on weight and appetite in patients with mild to moderate Alzheimer’s disease (AD) in relation to inflammatory biomarkers and apolipoprotein E epsilon4 (APOEepsilon4).; Design: Randomized, double-blind, placebo-controlled trial.; Setting: Specialist memory clinics in the Stockholm catchment area.; Participants: Two hundred four patients (aged […]

Faxén-Irving, Gerd, Freund-Levi, Yvonne, Eriksdotter-Jönhagen, Maria, Basun, Hans, Hjorth, Erik, Palmblad, Jan, Vedin, Inger, Cederholm, Tommy, Wahlund, Lars-Olof

Transthyretin (TTR) binds amyloid-β (Aβ) and may reduce brain Aβ, a pathological feature in Alzheimer’s disease (AD). N – 3 fatty acids (FA), docosahexaenoic (DHA), and eicosapentaenoic acid (EPA) may increase TTR transcription in rat hippocampus. We studied effects of n – 3 FA supplementation on TTR-levels in patients with AD. Outpatients were randomized to […]