Jessen, Frank, Wiese, Birgitt, Bickel, Horst, Eiffländer-Gorfer, Sandra, Fuchs, Angela, Kaduszkiewicz, Hanna, Köhler, Mirjam, Luck, Tobias, Mösch, Edelgard, Pentzek, Michael, Riedel-Heller, Steffi G., Wagner, Michael, Weyerer, Siegfried, Maier, Wolfgang, van den Bussche, Hendrik

Background: Current approaches for AD prediction are based on biomarkers, which are however of restricted availability in primary care. AD prediction tools for primary care are therefore needed. We present a prediction score based on information that can be obtained in the primary care setting.; Methodology/principal Findings: We performed a longitudinal cohort study in 3.055 […]

Jacobs, Emily G., Kroenke, Candyce, Lin, Jue, Epel, Elissa S., Kenna, Heather A., Blackburn, Elizabeth H., Rasgon, Natalie L.

Apolipoprotein-ε4 (APOE-ε4) is a major genetic risk factor for cognitive decline, Alzheimer’s disease (AD) and early mortality. An accelerated rate of biological aging could contribute to this increased risk. Here, we determined whether APOE-ε4 status impacts leukocyte telomere length (TL) and the rate of cellular senescence in healthy mid-life women and, further, whether hormone replacement […]

Ihara, Masafumi, Nishino, Madoka, Taguchi, Akihiko, Yamamoto, Yumi, Hattori, Yorito, Saito, Satoshi, Takahashi, Yukako, Tsuji, Masahiro, Kasahara, Yukiko, Takata, Yu, Okada, Masahiro

Goal: Combinatorial therapy directed at both vascular and neurodegenerative aspects of dementia may offer a promising strategy for treatment of dementia, which often has a multifactorial basis in the elderly. We investigated whether the phosphodiesterase III inhibitor cilostazol, which is often used in the prevention of stroke and peripheral artery disease, may delay cognitive decline […]

de Waal, Hanneke, Stam, Cornelis J., Lansbergen, Marieke M., Wieggers, Rico L., Kamphuis, Patrick J. G. H., Scheltens, Philip, Maestú, Fernando, van Straaten, Elisabeth C. W.

Background: Synaptic loss is a major hallmark of Alzheimer’s disease (AD). Disturbed organisation of large-scale functional brain networks in AD might reflect synaptic loss and disrupted neuronal communication. The medical food Souvenaid, containing the specific nutrient combination Fortasyn Connect, is designed to enhance synapse formation and function and has been shown to improve memory performance […]

Beer, Christopher, Horner, Barbara, Flicker, Leon, Scherer, Samuel, Lautenschlager, Nicola T., Bretland, Nick, Flett, Penelope, Schaper, Frank, Almeida, Osvaldo P.

Background: The Dementia In Residential care: EduCation intervention Trial (DIRECT) was conducted to determine if delivery of education designed to meet the perceived need of GPs and care staff improves the quality of life of participants with dementia living in residential care.; Methodology/principal Findings: This cluster-randomised controlled trial was conducted in 39 residential aged care […]