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This database contains 4 studies, archived under the term: "Journal of Neurology, Neurosurgery & Psychiatry"

No effect of donepezil on striatal dopamine release in mild to moderate Alzheimer’s disease

Objective: Work in experimental animals suggests that an interaction with dopaminergic networks might explain some of the therapeutic effects of the cholinesterase inhibitor class of drugs. This study aimed to test whether acute (single 5 mg) or 4–8 weeks (5–10 mg) of treatment with oral donepezil would elicit measurable striatal dopamine (DA) release in patients […]

Behavioural abnormalities associated with rapid deterioration of language functions in semantic dementia respond to sertraline

Frontotemporal dementia (FTD) consists of three main clinical syndromes: (1) frontal variant FTD presenting predominantly with behavioral abnormalities, (2) semantic dementia presenting with fluent aphasic deficits and (3) primary progressive aphasia presenting with non-fluent aphasic deficits. We have observed that significant behavioral problems may occur in some patients with semantic dementia when both comprehension and […]

Isolated theory of mind deficits and risk for frontotemporal dementia: A longitudinal pilot study

Objective: Recent data suggest that theory of mind (ToM) deficits represent an early symptom of the behavioural variant of frontotemporal dementia (bvFTD). However, longitudinal data on the natural history of subjects presenting with isolated ToM deficits are lacking. The aim of the study was to verify if isolated ToM deficits represent an at-risk state for […]

Mediterranean diet improves cognition: The PREDIMED-NAVARRA randomised trial

Objective: Previous observational studies reported beneficial effects of the Mediterranean diet (MedDiet) on cognitive function, but results were inconsistent. We assessed the effect on cognition of a nutritional intervention using MedDiets in comparison with a low-fat control diet. Methods: We assessed 522 participants at high vascular risk (44.6% men, age 74.6 ± 5.7 years at […]

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