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This database contains 5 studies, archived under the term: "Aging Clinical And Experimental Research"

Cognitive intervention response is related to habitual physical activity in older adults

Background and Aims: This study analysed the associations between physical activity and the effects of cognitive training on perceived cognitive functioning and life satisfaction in older adults.; Methods: A sample of 114 intervention group participants (65-89 yrs) received weekly group sessions of cognitive stimulation for two months. This sample was stratified into groups according to […]

Does a multicomponent exercise program improve dual-task performance in amnestic mild cognitive impairment? A randomized controlled trial

Background and Aims: There has been much interest in exercise interventions as a primary behavioral prevention strategy against cognitive decline. The aim of this study was to evaluate the effect of a multicomponent exercise program on physical and dual-task performances in community-dwelling older adults with amnestic mild cognitive impairment (aMCI).; Methods: Fifty older adults (23 […]

One-year repeated cycles of cognitive training (CT) for Alzheimer’s disease

Background: Recent research suggests that a combination of both pharmacological and psychosocial treatments targeting cognitive functions improves cognition in patients with Alzheimer’s disease (AD). The present study evaluated the effectiveness of a 1-year cognitive training (CT) by comparing the cognitive performance of 16 patients with AD treated with CT and cholinesterase inhibitors (ChEIs) (experimental group) […]

A randomized controlled study on effects of ibuprofen on cognitive progression of Alzheimer’s disease

Background and Aims: Epidemiological studies have examined the association between the use of non-steroidal anti-inflammatory drugs (NSAIDs) and the risk of Alzheimer’s disease (AD). Recently, a variety of experimental studies indicates that a subset of NSAIDs, such as ibuprofen or flurbiprofen, also have Abeta-lowering properties in both AD transgenic mice and cell cultures of peripheral, […]

Testosterone effect on brain metabolism in elderly patients with Alzheimer’s disease: comparing two cases at different disease stages

Objective: To describe the effect of testosterone replacement therapy (TRT) on the brain activity of two demented, hypogonadal male patients with early and late-stage Alzheimer’s disease (AD), respectively.; Methods: We describe the clinical and positron emission tomography (PET) findings for two individuals, one with early stage and the other with late-stage Alzheimer’s disease, before and […]

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