Kieburtz, Karl, Landwehrmeyer, G. B., HORIZON Investigators of the Huntington Study Group,, European Huntington's Disease Network,

BACKGROUND Latrepirdine is an orally administered experimental small molecule that was initially developed as an antihistamine and subsequently was shown to stabilize mitochondrial membranes and function, which might be impaired in Huntington disease. OBJECTIVE To determine the effect of latrepirdine on cognition and global function in patients with mild to moderate Huntington disease. DESIGN Randomized, […]

Talarowska, Monika, Krzysztof, Zboralski, Mossakowska-Wójcik, Joanna, Gałecki, Piotr

Aim: Coexistence of depression and dementia for many years has been widely studied for many years. According to the authors for clinical practice, both psychiatric and psychological, it is also important to effectively differentiate between these disease entities. The aim of this study is to compare the implementation of the Trail Making Test (TMT) in […]

Stoeck, K., Sanchez-Juan, P., Gawinecka, J., Green, A., Ladogana, A., Pocchiari, M., Sanchez-Valle, R., Mitrova, E., Sklaviadis, T., Kulczycki, J., Slivarichova, D., Saiz, A., Calero, M., Knight, R., Aguzzi, A., Laplanche, J.-L., Peoc'h, K., Schelzke, G., Karch, A., van Duijn, C. M., Zerr, I.

To date, cerebrospinal fluid analysis, particularly protein 14-3-3 testing, presents an important approach in the identification of Creutzfeldt-Jakob disease cases. However, one special point of criticism of 14-3-3 testing is the specificity in the differential diagnosis of rapid dementia. The constant observation of increased cerebrospinal fluid referrals in the national surveillance centres over the last […]