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This database contains 90 studies, archived under the term: "Australia"

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The PACE study: a randomized clinical trial of cognitive activity strategy training for older people with mild cognitive impairment

Objective: The role of cognition-focused interventions in reducing cognitive decline in older people remains uncertain. This study aimed to clarify whether a group cognitive activity (CA) strategy-training program would decrease the 2-year rate of cognitive decline of people with mild cognitive impairment (MCI).; Design: Randomized controlled trial.; Setting: One study site.; Participants: 160 older adults […]

Vitamins B₁₂, B₆, and folic acid for cognition in older men

[Correction Notice: An erratum for this article was reported in Vol 77(8) of Neurology (see record [rid]2011-21984-022[/rid]). In the original article, the daily dose of vitamin B12 used in the trial was reported as 400 μg, but it should have been 500 μg.] Objective: To investigate whether supplementing older men with vitamins B12, B6, and […]

Delivering a music intervention in a randomized controlled trial involving older people with dementia: Musician experiences and reflections

A qualitative thematic approach was used to explore musicians’ views and experiences of delivering a music intervention and its efficacy for people with dementia in long-term care. Two musicians who delivered the intervention in a randomized controlled trial were interviewed using a semistructured schedule. The data were sorted, categorized, and thematically analyzed. Two themes emerged: […]

Addressing population aging and Alzheimer’s disease through the Australian Imaging Biomarkers and Lifestyle Study: Collaboration with the Alzheimer’s Disease Neuroimaging Initiative

The Australian Imaging Biomarkers and Lifestyle (AIBL) study is a longitudinal study of 1112 volunteers from healthy, mild cognitive impairment, and Alzheimer’s disease (AD) populations who can be assessed and followed up for prospective research into aging and AD. AIBL aims to improve understanding of the pathogenesis, early clinical manifestation, and diagnosis of AD, and […]

Effect of physical activity on cognitive function in older adults at risk for Alzheimer disease: A randomized trial

Context: Many observational studies have shown that physical activity reduces the risk of cognitive decline; however, evidence from randomized trials is lacking. Objective: To determine whether physical activity reduces the rate of cognitive decline among older adults at risk. Design and Setting: Randomized controlled trial of a 24-week physical activity intervention conducted between 2004 and […]

Managing agitated behaviour in people with Alzheimer’s disease: The role of live music

Background: Agitation due to Alzheimer’s disease (AD) presents a challenge to occupational therapists working in the older people care sector. Recently background music and music therapy have emerged as promising tools in the management of agitation in AD. This exploratory study investigated whether live music could reduce agitated behaviour in people with AD. Method: A […]

Randomized controlled trial of a Healthy Brain Ageing Cognitive Training program: Effects on memory, mood, and sleep

Background: With the rise in the ageing population and absence of a cure for dementia, cost-effective prevention strategies for those ‘at risk’ of dementia including those with depression and/or mild cognitive impairment are urgently required. Objective: This study evaluated the efficacy of a multifaceted Healthy Brain Ageing Cognitive Training (HBA-CT) program for older adults ‘at […]

Study design of ASPirin in Reducing Events in the Elderly (ASPREE): a randomized, controlled trial

Cost-effective strategies to maintain healthy active lifestyle in aging populations are required to address the global burden of age-related diseases. ASPREE will examine whether the potential primary prevention benefits of low dose aspirin outweigh the risks in older healthy individuals. Our primary hypothesis is that daily oral 100 mg enteric-coated aspirin will extend a composite […]

A community-based exercise programme to improve functional ability in people with Alzheimer’s disease: a randomized controlled trial

Rationale: Dementia is a common neurodegenerative condition in older age associated with functional decline across multiple domains. This decline impacts not only on the person with dementia, but also on their informal carers and health and aged care systems. With the number of people with dementia rapidly increasing and few effective treatments, there is now […]

Study protocol: a randomised controlled trial of the effects of a multi-modal exercise program on cognition and physical functioning in older women

Background: Intervention studies testing the efficacy of cardiorespiratory exercise have shown some promise in terms of improving cognitive function in later life. Recent developments suggest that a multi-modal exercise intervention that includes motor as well as physical training and requires sustained attention and concentration, may better elicit the actual potency of exercise to enhance cognitive […]

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