This database contains 59 studies, archived under the term: "Spain"
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A phase II trial of tideglusib in Alzheimer’s disease
Lovestone, Simon,
Boadab, Mercè,
Dubois, Bruno,
Hüll, Michael,
Rinne, Juha O.,
Huppertz, Hans-Jürgen,
Calero, Miguel,
Andrés, María V.,
Gómez-Carrillo, Belén,
Leon, Teresa,
del Seri, Teodoro
Background: The ARGO study was a phase II, double-blind, placebo controlled, four parallel arm trial of tideglusib in Alzheimer’s disease (AD). Objective: To prove the clinical efficacy of an inhibitor of glycogen synthase kinase-3 (GSK-3), in AD. Methods: Mild to moderate (Mini-Mental State Examination (MMSE) score, 14–26) AD patients on cholinesterase inhibitor and/or memantine treatment […]
Risk of cerebrovascular accident associated with use of antipsychotics: population-based case-control study
Laredo, Leonor,
Vargas, Emilio,
Blasco, Antonio Javier,
Aguilar, Maria Dolores,
Moreno, Alfonso,
Portolés, Antonio
Objectives: To explore the association between use of antipsychotics and risk of cerebrovascular accident (CVA) in individuals with dementia aged 65 and older.; Design: Population-based case-control study.; Setting: UK-based electronic primary care records in the General Practice Research Database (GPRD).; Participants: Individuals with dementia aged 65 and older registered in the database between January 1, […]
Long-term safety of rivastigmine in parkinson disease dementia: an open-label, randomized study
Emre, Murat,
Poewe, Werner,
De Deyn, Peter Paul,
Barone, Paolo,
Kulisevsky, Jaime,
Pourcher, Emmanuelle,
van Laar, Teus,
Storch, Alexander,
Micheli, Federico,
Burn, David,
Durif, Frank,
Pahwa, Rajesh,
Callegari, Francesca,
Tenenbaum, Nadia,
Strohmaier, Christine
Objective: This study investigated the long-term safety of rivastigmine (12 mg/d capsules, 9.5 mg/24 h patch) and effects on motor symptoms in patients with mild-to-moderately severe Parkinson disease dementia.; Methods: This was a 76-week, prospective, open-label, randomized study in patients aged 50 to 85 years. Primary outcomes included incidence of, and discontinuation due to, predefined […]
Efectos del Modelo de Atención Centrado en la Persona en la calidad de vida de personas con deterioro cognitivo de centros gerontológicos. = Effects from the Person Centered-Care Model on quality of life of cognitive impaired persons from gerontological centers
Díaz-Veiga, Pura,
Sancho, Mayte,
García, Álvaro,
Rivas, Esther,
Abad, Elixabet,
Suárez, Nerea,
Mondragón, Gabriela,
Buiza, Cristina,
Orbegozo, Ana,
Yanguas, Javier
Introduction: The Model of Person Centered Care has attracted increasing interest for use in gerontology centers. Therefore, the contributions about its impact are scarce in our context. The objective of this paper is to establish the impact that the interventions associated with the Model of Person Centered Care in the «Etxean Ondo» Project have on […]
Safety and effectiveness of donepezil on behavioral symptoms in patients with Alzheimer disease
The objective of this study was to evaluate the prevalence and treatment responsiveness of neuropsychiatric symptoms in patients with mild to moderately severe Alzheimer disease recruited in a naturalistic treatment setting in Spain. All the patients, who matched the prescribing recommendations for donepezil and were able to participate in the study, received donepezil (5 to […]
Risk of incident dementia in drug-untreated arterial hypertension: a population-based study
Bermejo-Pareja, Félix,
Benito-León, Julián,
Louis, Elan D.,
Trincado, Rocío,
Carro, Eva,
Villarejo, Alberto,
de la Cámara, Agustín Gómez
Arterial hypertension in midlife may increase the risk of late-life dementia. Notably, there is conflicting data as to whether hypertension in the elderly (age 65 years and older) is a risk factor for dementia and Alzheimer’s disease (AD). We determined whether drug-untreated hypertension was associated with a higher risk of incident dementia and AD. In […]