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Statins as neuroprotectants: a comparative in vitro study of lipophilicity, blood-brain-barrier penetration, lowering of brain cholesterol, and decrease of neuron cell death
Sierra, Saleta,
Ramos, Maria C.,
Molina, Pilar,
Esteo, Cynthia,
Vázquez, Jose Antonio,
Burgos, Javier S.
...neurodegenerative conditions due to their higher potential BBB penetration capacity, cholesterol lowering effect on neurons with a satisfactory safety profile, and in vitro protection against cell death caused by okadaic...
Effect of treatment gaps in elderly patients with dementia treated with cholinesterase inhibitors
Pariente, A.,
Fourrier-Reglat, A.,
Bazin, F.,
Ducruet, T.,
Dartigues, J. F.,
Dragomir, A.,
Perreault, S.,
Moore, N.,
Moride, Y.
...Objective: To determine the effect of treatment gaps on the risk of institutionalization or death among community-dwelling elderly patients treated with cholinesterase inhibitors (ChIs).; Methods: A survival analysis was...
The dementia antipsychotic withdrawal trial (DART-AD): long-term follow-up of a randomised placebo-controlled trial
Ballard, Clive,
Hanney, Maria Luisa,
Theodoulou, Megan,
Douglas, Simon,
McShane, Rupert,
Kossakowski, Katja,
Gill, Randeep,
Juszczak, Edmund,
Yu, Ly-Mee,
Jacoby, Robin
...death were obtained from death certificates. Analysis was by intention to treat (ITT) and modified intention to treat (mITT). This trial is registered with the Cochrane Central Registry of Controlled...
Long-term metformin usage and cognitive function among older adults with diabetes
Ng, Tze Pin,
Feng, Liang,
Yap, Keng Bee,
Lee, Tih Shih,
Tan, Chay Hoon,
Winblad, Bengt
Evidence strongly supports the important role of insulin resistance in cognitive decline and dementia and suggests that insulin sensitizers may protect against cognitive decline in diabetic and pre-diabetic...
Pet therapy in elderly patients with mental illness
MORETTI, Francesca,
DE RONCHI, Diana,
BERNABEI, Virginia,
MARCHETTI, Lucia,
FERRARI, Barbara,
FORLANI, Claudia,
NEGRETTI, Francesca,
SACCHETTI, Cleta,
ATTI, Anna Rita
...Background: To evaluate the effects of pet therapy on cognitive function, mood and perceived quality of life on elderly inpatients (mean age 84.7 years; 95.2% women) affected by dementia,...